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Your Vote Counts! *Please check the meeting materials for any special requirements for meeting attendance. Smartphone users Point your camera here and vote without entering a control number For complete information and to vote, visit www.ProxyVote.com Control # V48318-P11070 MEIRAGTX HOLDINGS PLC 450 EAST 29TH STREET, 14TH FLOOR NEW YORK, NY 10016 MEIRAGTX HOLDINGS PLC 2024 Annual Meeting Vote by June 5, 2024 11:59 PM ET You invested in MEIRAGTX HOLDINGS PLC and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy materials for the shareholder meeting to be held on June 6, 2024. Vote Virtually at the Meeting* June 6, 2024 10:00 AM Eastern Time Virtually at: www.virtualshareholdermeeting.com/MGTX2024 Get informed before you vote View the Notice of Annual General Meeting, Proxy Statement and Annual Report on Form 10-K online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 23, 2024. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy.


Vote at www.ProxyVote.com Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Delivery Settings”. Voting Items Board Recommends V48319-P11070 1. Election of Directors For Nominees: 01) Alexandria Forbes, Ph.D. 02) Keith R. Harris, Ph.D. 03) Lord Mendoza 2. To approve, on an advisory (non-binding) basis, the compensation of the Company’s named executive officers. For 3. To approve, on an advisory (non-binding) basis, the frequency of future advisory votes on the compensation of the Company’s named executive officers. 3 Years 4. To ratify, by ordinary resolution, the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2024. For NOTE: To transact such other business as may properly come before the Annual Meeting or any continuation, postponement or adjournment thereof. THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming shareholder meeting. Please follow the instructions on the reverse side to vote these important matters.